Mishra & Kumar (2024)
Heliyon 2024;10(17):e36885
Anxiety (HAMA) fell 59% with both doses versus a 0.83% rise on placebo, morning cortisol fell 66-67% and perceived stress 53-62%.
- RCT, double-blind
- n=60
- 60-120 mg/day
- 60 days
Full summary
A randomized, double-blind, placebo-controlled trial in 60 physically healthy adults with high stress and anxiety (HAMA >20, raised morning cortisol) compared Shoden® at 60 mg/day or 120 mg/day with placebo for 60 days. Anxiety (HAMA) fell 59% with both doses versus a 0.83% rise on placebo, morning cortisol fell 66-67% and perceived stress 53-62%. In men, testosterone rose 22% and 33% versus 4% on placebo.




